纯干货---医学肠道微生物文章集锦，给您最全方位的参考-科研进展-上海天昊生物-微生物绝对定量测序、宏基因组测序、甲基化检测、单细胞转录组测序、转录组测序、外泌体检测

纯干货---医学肠道微生物文章集锦，给您最全方位的参考

如今医学微生物多样性研究热度持续高涨，而从大型微生物组的研究分析来看，肠道微生物相关研究在人类微生物组中所占的百分比最大，占据了全部研究的一半以上。目前扩增子测序和宏基因组测序在人类肠道微生物研究中使用越来越广泛，但是大家苦于找寻自己所研究疾病的相关扩增子测序文章和宏基因组文章（例如我所研究的疾病样本扩增子测序该使用什么区段呢？），下面我们就盘点一下各种疾病进行肠道微生物研究的典型案例！

高血压

英文题目	期刊名称	影响因子	发表时间	测序策略
Gut microbiota dysbiosis contributes to the development of hypertension	Microbiome	9	2017	扩增子测序（16S V4）宏基因组测序
Hypertension-Linked Pathophysiological Alterations in the Gut	circulation research	11.551	2017	扩增子测序（16S V4-V5）
High Fibre Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in DOCA-Salt Hypertensive Mice	Circulation	8.52	2016	扩增子测序（16S V3-V4）
Role of the Gut Microbiome in Obstructive Sleep Apnea-Induced Hypertension	Hypertension	6.294	2016	扩增子测序（16S V3-V5）
Gut Dysbiosis Is Linked to Hypertension	Hypertension	6.294	2015	扩增子测序（16S V4-V5）
Evidence for a link between gut microbiota and hypertension in the Dahl rat	physiological genomics	2.615	2015	扩增子测序（16S V4-V5）

糖尿病

英文题目	期刊名称	影响因子	发表时间	测序策略
The stool microbiota of insulin resistant women with recent gestational diabetes, a high risk group for type 2 diabetes	Scientific Reports	5.228	2015	扩增子测序（16S V4）
Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota	Nature	38.138	2015	宏基因组测序
Gut metagenome in European women with normal, impaired and diabetic glucose control.	Nature	38.138	2013	宏基因组测序
A metagenome-wide association study of gut microbiota in type 2 diabetes	Nature	38.138	2012	宏基因组测序
Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults	Plos one	3.0100	2010	扩增子测序（16S V4-V6）

肥胖

英文题目	期刊名称	影响因子	发表时间	测序策略
Insoluble dietary fiber from pear pomace can prevent high-fat diet induced obesity in rats mainly by improving the structure of gut microbiota.	J Microbiol Biotechnol	1.685	2017	扩增子测序（16S V4）
Melatonin prevents obesity through modulation of gut microbiota in mice	J Pineal Res	9.314	2017	扩增子测序（16S V3-V4）
Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology	Gut	14.921	2016	宏基因组测序
Richness of human gut microbiome correlates with metabolic markers	Nature	38.138	2013	宏基因组测序
A core gut microbiome in obese and lean twins	Nature	38.138	2009	扩增子测序（16S V2/V6）

高胆固醇血症

英文题目	期刊名称	影响因子	发表时间	测序策略
Diet-Induced Metabolic Improvements in a Hamster Model of Hypercholesterolemia Are Strongly Linked to Alterations of the Gut Microbiota	Applied and environmental microbiology	3.823	2009	扩增子测序（16S V1-V3）
Effects of deep sea water and Lactobacillus paracasei subsp. paracasei NTU 101 on hypercholesterolemia hamsters gut microbiota	Appl Microbiol Biotechnol	3.376	2017	扩增子测序（16S V3）

帕金森综合症

英文题目	期刊名称	影响因子	发表时间	测序策略
Gut Microbiota Regulate Motor Deficits and neuroinflammation in a Model of Parkinson’s Disease	Cell	28.71	2016	扩增子测序（16S V4）
Colonic bacterial composition in arkinson’s disease	Mov Disord	6.01	2015	扩增子测序（16S V4）
Gut microbiota are related to Parkinson's disease and clinical phenotype	Mov Disord	6.01	2015	扩增子测序（16S V1-V3）

自闭症

英文题目	期刊名称	影响因子	发表时间	测序策略
Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study	Microbiome	9	2017	扩增子测序（16S V4）
Analysis of the Duodenal Microbiome in Autistic Individuals: Association with Carbohydrate Digestion	J Pediatr Gastroenterol Nutr	2.4	2016	扩增子测序（16S V1-V3）
Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified	Plos one	3.0100	2013	扩增子测序（16S V1-V3）
Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children	Plos one	3.0100	2013	扩增子测序（16S V2-V3）

慢性疲劳综合症

英文题目	期刊名称	影响因子	发表时间	测序策略
Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome	Microbiome	9	2016	扩增子测序（16S V4）
Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)	Plos one	3.0100	2015	扩增子测序（16S V1-V3）
High-throughput 16S rRNA gene sequencing reveals alterations of intestinal microbiota in myalgic encephalomyelitis/chronic fatigue syndrome patients	anaerobe	2.24	2013	扩增子测序（16S V5）

动脉粥样硬化

英文题目	期刊名称	影响因子	发表时间	测序策略
Lingonberries reduce atherosclerosis in Apoe -/- mice in association with altered gut microbiota composition and improved lipid profile	Mol. Nutr. Food Res	4.551	2016	扩增子测序（16S）
In silico analyses of metagenomes from human atherosclerotic plaque samples	Microbiome	9	2015	宏基因组测序
Symptomatic atherosclerosis is associated with an altered gut metagenome	Nature communications	11.329	2012	宏基因组测序
Human oral, gut, and plaque microbiota in patients with atherosclerosis	PNAS	9.423	2011	扩增子测序（16S V1-V2）

中风

英文题目	期刊名称	影响因子	发表时间	测序策略
Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke	The Journal of Neuroscience	5.924	2016	扩增子测序（16S V1-V3）
Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells	Nature medicine	30.3100	2015	扩增子测序（16S V4-V5）

强直性脊柱炎

英文题目	期刊名称	影响因子	发表时间	测序策略
Intestinal Dysbiosis in Ankylosing Spondylitis	Arthritis Rheumatol	6.009	2015	扩增子测序（16S V4）

关节炎

英文题目	期刊名称	影响因子	发表时间	测序策略
Alteration of Fecal Microbiota Profiles in Juvenile Idiopathic Arthritis. Associations with HLA-B27 Allele and Disease Status	Frontiers in Microbiology	4.165	2016	扩增子测序（16S V5-V6）
Decreased Bacterial Diversity Characterizes the Altered Gut Microbiota in Patients With Psoriatic Arthritis, Resembling Dysbiosis in Inflammatory Bowel Disease	Arthritis Rheumatol	6.009	2015	扩增子测序（16S V1-V2）
The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment	Nature medicine	30.3100	2015	宏基因组测序

原发性胆汁性胆管炎

英文题目	期刊名称	影响因子	发表时间	测序策略
Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy	Gut	14.921	2017	扩增子测序（16S V3-V4）

胆结石

英文题目	期刊名称	影响因子	发表时间	测序策略
Interactions between the intestinal microbiota and bile acids in gallstones patients	Environmental Microbiology Reports	3.5	2015	扩增子测序（16S）
Gut microbiota dysbiosis and bacterial community assembly associated with cholesterol gallstones in large-scale study	BMC Genomics	3.867	2013	扩增子测序（16S V1-V2）

肠易激综合征

英文题目	期刊名称	影响因子	发表时间	测序策略
Identification of an Intestinal Microbiota Signature Associated With Severity of Irritable Bowel Syndrome	Gastroenterology	7.67	2017	扩增子测序（16S V5-V6）
The human intestinal microbiota of constipated-predominant irritable bowel syndrome patients exhibits anti-inflammatory properties	Scientific Reports	5.228	2016	扩增子测序（16S V5-V6）
Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity	Science	34.1001	2016	扩增子测序（16S V4）宏基因组测序
Reduction of butyrate- and methane-producing microorganisms in patients with Irritable Bowel Syndrome	Scientific Reports	5.228	2015	扩增子测序（16S V4）
An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota	Gut	14.921	2011	扩增子测序（16S V4）

结直肠癌

英文题目	期刊名称	影响因子	发表时间	测序策略
Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer	Gut	14.921	2017	宏基因组测序
Systematic evaluation of supervised classifiers for fecal microbiota-based prediction of colorectal cancer	Oncotarget	5.008	2016	扩增子测序（16S V1-V3）
Gut mucosal microbiome across stages of colorectal carcinogenesi	Nature communications	11.329	2015	扩增子测序（16S V1-V4）
Gut microbiome development along the colorectal adenoma–carcinoma sequence	Nature communications	11.329	2015	宏基因组测序
Potential of fecal microbiota for early-stage detection of colorectal cancer	Mol Syst Biol.	10.581	2014	扩增子测序（16S V4）宏基因组测序
Co-occurrence of driver and passenger bacteria in human colorectal cancer.	Gut Pathogens	2.816	2014	扩增子测序（16S V1-V2）
Human Intestinal Lumen and Mucosa-Associated Microbiota in Patients with Colorectal Cancer	Plos one	3.0100	2012	扩增子测序（16S V1-V3）
Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers	The ISME Journal	9.328	2012	扩增子测序（16S V3）
Towards the Human Colorectal Cancer Microbiome.	Plos one	3.0100	2011	扩增子测序（16S V1-V3）

脂肪肝

英文题目	期刊名称	影响因子	发表时间	测序策略
Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice	Gut	14.921	2013	扩增子测序（16S V3-V4）
Fecal microbiome and volatile organic compound metabolome in obese humans with nonalcoholic fatty liver disease.	Clin Gastroenterol Hepatol	7.68	2013	扩增子测序（16S V1-V2）
Molecular characterization of the fecal microbiota in patients with nonalcoholic steatohepatitis–a longitudinal study	Plos one	3.0100	2013	扩增子测序（16S V1-V2）
Association Between Composition of the Human Gastrointestinal Microbiome and Development of Fatty Liver With Choline Deficiency	Gastroenterology	18.187	2011	扩增子测序（16S V1-V2）

肝硬化

英文题目	期刊名称	影响因子	发表时间	测序策略
Alterations of the human gut microbiome in liver cirrhosis	Nature	38.138	2014	宏基因组测序
Alterations and correlations of the gut microbiome, metabolism and immunity in patients with primary biliary cirrhosis	Environ Microbiol	5.932	2016	扩增子测序（16S V3-V4）
Gut Microbiota Alterations can predict Hospitalizations in Cirrhosis Independent of Diabetes Mellitus	Scientific Reports	5.228	2015	扩增子测序（16S V1-V2）
Intestinal Lesions Are Associated with Altered Intestinal Microbiome and Are More Frequent in Children and Young Adults with Cystic Fibrosis and Cirrhosis	Plos one	3.0100	2015	扩增子测序（16S V4）

脂肪肝炎

英文题目	期刊名称	影响因子	发表时间	测序策略
Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH.	Hepatology	11.711	2013	扩增子测序（16S）

病毒性肝炎

英文题目	期刊名称	影响因子	发表时间	测序策略
Gut microbiome alterations in patients with stage 4 hepatitis C	Gut Pathogens	2.816	2016	扩增子测序（16S V4）
A Novel “Humanized Mouse” Model for Autoimmune Hepatitis and the Association of Gut Microbiota With Liver Inflammation	Hepatology	11.711	2015	扩增子测序（16S V2）

肝癌

英文题目	期刊名称	影响因子	发表时间	测序策略
Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity	Cancer discovery	19.783	2017	扩增子测序（16S V4）
Distinctly altered gut microbiota in the progression of liver disease	Oncotarget	5.008	2016	扩增子测序（16S V1-V3）

坏死性小肠结肠炎

英文题目	期刊名称	影响因子	发表时间	测序策略
Gut bacteria dysbiosis and necrotising enterocolitis in very low birthweight infants: a prospective case-control study	Lancet	44.002	2016	扩增子测序（16S V3-V5）
A necrotizing enterocolitis-associated gut microbiota is already present in the meconium: results of a prospective study	Clin Infect Dis	8.736	2016	扩增子测序（16S V3-V4）
The Microbiome in Necrotizing Enterocolitis: A Case Report in Twins and Minireview	Clinical Therapeutics	2.925	2016	扩增子测序（16S V3-V4）

溃疡性结肠炎

英文题目	期刊名称	影响因子	发表时间	测序策略
Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial	Lancet	44.002	2017	扩增子测序（16S V1-V3）
Spatial variation of the colonic microbiota in patients with ulcerative colitis and control volunteers	Gut	14.921	2015	扩增子测序（16S V4）
Characterization of Intestinal Microbiota in Ulcerative Colitis Patients with and without Primary Sclerosing Cholangitis	Journal of Crohn's and Colitis	6.585	2015	扩增子测序（16S V4）

黑色素瘤

英文题目	期刊名称	影响因子	发表时间	测序策略
Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis	Nature communications	11.329	2016	扩增子测序（16S V4-V5）

前列腺炎

英文题目	期刊名称	影响因子	发表时间	测序策略
Analysis of gut microbiome reveals significant differences between men with chronic prostatitis/chronic pelvic pain syndrome and controls	Journal of urology	4.7	2016	扩增子测序（16S）

巨结肠病

英文题目	期刊名称	影响因子	发表时间	测序策略
Characterization of Intestinal Microbiomes of Hirschsprung’s Disease Patients with or without Enterocolitis Using Illumina-MiSeq High-Throughput Sequencing	Plos one	3.0100	2016	扩增子测序（16S V4）
Characterization of Bacterial and Fungal Microbiome in Children with Hirschsprung Disease with and without a History of Enterocolitis: A Multicenter Study	Plos one	3.0100	2015	扩增子测序（16S V1-V3/ ITS1）
Characterization of the intestinal microbiome of Hirschsprung’s disease with and without enterocolitis	Biochem Biophys Res Commun	2.371	2014	扩增子测序（16S V1-V3）

系统性红斑狼疮

英文题目	期刊名称	影响因子	发表时间	测序策略
Alterations of the gut microbiome in Chinese patients with systemic lupus erythematosus	Gut Pathogens	2.816	2016	扩增子测序（16S V4）
Association of Polyphenols from Oranges and Apples with Specific Intestinal Microorganisms in Systemic Lupus Erythematosus Patients	Nutrients	3.759	2015	扩增子测序（16S V3）
Intestinal dysbiosis associated with systemic lupus erythematosus	MBio	6.975	2014	扩增子测序（16S V3）

多囊卵巢综合征

英文题目	期刊名称	影响因子	发表时间	测序策略
Alterations in Gut Microbiome Composition and Barrier Function Are Associated with Reproductive and Metabolic Defects in Women with Polycystic Ovary Syndrome (PCOS): A Pilot Study.	Plos one	3.0100	2017	扩增子测序（16S V1-V2）
The Salivary Microbiome in Polycystic Ovary Syndrome (PCOS) and Its Association with Disease-Related Parameters: A Pilot Study	Frontiers in Microbiology	4.165	2016	扩增子测序（16S V1-V2）
The Gut Microbiome Is Altered in a Letrozole-Induced Mouse Model of Polycystic Ovary Syndrome	Plos one	3.0100	2016	扩增子测序（16S V4）

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