不做实验，挖掘两个GWAS癌症数据，可以发表5分文章？
        我可能看了假的文章……但是同样研究思路的，还不止一篇……
        2017年新鲜出炉的文章Genetic variants in the integrin signaling pathway genes predict cutaneous melanoma survival，发表在INTERNATIONAL JOURNAL OF CANCER（IF=5.531）。
   
       这篇文章小编能看出的不同，只有关注了一条pathway，当然还有就是研究的预后生存，不是发病率……
 
       Word天哪，难道就这么简单？这完全不是传统的研究思路啊！小编搜了一下，发现……这样思路的不止一篇！
 
        2016年发表在ONCOTARGET（IF=5.008）上的文章Genetic polymorphisms of Wnt/β-catenin pathway genes are associated with the effiacy and toxicities of radiotherapy in patients with nasopharyngeal carcinoma.
        挑选Wnt/β-catenin通路4个核心蛋白CTNNB1(编码β-catenin蛋白)，GSK3β，APC，Wnt2的9个SNPs位点。在188个鼻咽癌病人中验证这些SNP位点与放疗效果和毒性的关系。
 
        再搜索了一下，小编发现3年前这样的思路，发表了11分的文章，感觉错过了全世界……
 
       2014年JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE杂志（IF=11.37）就发表了这种基于pathway分析进行的SNP关联研究的文章：Insulin-like growth factor pathway genetic polymorphisms, circulating IGF1 and IGFBP3, and prostate cancer survival.
       在5,887个胰腺癌病人中，分析类胰岛素生长因子信号通路的26个基因的590个SNP位点与胰腺癌预后生存的相关性。
 
        数据库文献的思路可以复制么？天昊的客户真的做到了！两个癌种血液样品，三个研究领域（miRNA、免疫、代谢和凋亡）客户采用天昊生物自主专利SNP分型技术，三年发表10篇SCI！
        1、打破传统的验证单一基因单一位点的SNP挑选方法，选取一条发挥关键作用的信号通路为研究目标
      2、 除了传统的SNP与发病率的关系，任何临床可以量化的指标都可以进行分析，如预后、放化疗不良反应、转移、复发等等。
 
参考文献：
      1、Genetic variants in the integrin signaling pathway genes predict cutaneous melanoma survival. Int J Cancer. 2017 Mar 15; 140(6):1270-1279.
      2、Genetic polymorphisms of Wnt/β-catenin pathway genes are associated with the effiacy and toxicities of radiotherapy in patients with nasopharyngeal carcinoma. Oncotarget, 2016, Vol. 7, (No. 50), pp: 82528-82537
      3、Insulin-like growth factor pathway genetic polymorphisms, circulating IGF1 and IGFBP3, and prostate cancer survival. J Natl Cancer Inst. 2014 Jun; 106(6):dju085.
      4、The variant interleukin 1f7 rs3811047 G>A was associated with a decreased risk of gastric cardiac adenocarcinoma in a Chinese Han population. Tumor Biol. 2013, DOI 10.1007/s13277-013-1463-y.
      5、Interleukin 17A rs4711998 A >G polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population. Diseases of the Esophagus (2013), DOI: 10.1111/dote.12045.
      6、Interleukin 1B rs16944 G > A polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population. Clinical Biochemistry 46 (2013) 1469–1473.
      7、IL-15 receptor alpha rs2228059 A>C polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population. Mol Biol Rep (2014) 41:1951–1957.
      8、Interleukin 17A rs3819024 A>G polymorphism is associated with an increased risk of gastric cardia adenocarcinoma in a Chinese population. Biomarkers, 2014; 19(5): 411–416.
      9、Interleukin 10 rs1800872 T>G Polymorphism was Associated with an Increased Risk of Esophageal Cancer in a Chinese Population. Asian Pacifi J Cancer Prev, 14 (6), 3443-3447.
      10、Interleukin 12B rs3212227 T > G polymorphism was associated with an increased risk of gastric cardiac adenocarcinoma in a Chinese population. Diseases of the Esophagus (2015) 28, 291–298.
      11、MiR-196a2 rs11614913 T > C polymorphism and risk of esophageal cancer in a Chinese population. Human Immunology 74 (2013) 1199–1205.
      12、Caspase8 rs1035142 G>T polymorphism was associated with an increased risk of esophageal cancer in a Chinese population. Mol Biol Rep (2014) 41:2037–2043.
      13、B-cell Lymphoma 2 rs17757541 C>G Polymorphism was Associated with an Increased Risk of Gastric Cardiac Adenocarcinoma in a Chinese Population. Asian Pac J Cancer Prev, 14 (7), 4301-4306.