摘要：
       单个目的基因测序的10篇精彩模板文章
       有灵感，天昊过硬的技术帮您实现灵感~
       没有灵感，天昊专业的团队也可以帮您寻找灵感~
 
       目标区域测序（Targeted Sequencing），顾名思义是指针对感兴趣的目标区域富集后进行大规模测序。作为外显子测序的一种变异形式，目标区域测序有三个明显的优势：目标区域选择灵活，测序深度高，费用低。这些技术优势，使得目标区域测序在复杂疾病的研究中得到了广泛的应用。对于复杂疾病的研究 ，目的区域测序不仅可以作为其它技术研究结果的后续纵深扩展，而且可以单独作为整篇文章的技术支撑。
 
天昊目的区域测序用于研究的纵深扩展案例：
        ?    Whole-exome and targeted sequencing identifyROBO1 and ROBO2 mutations as progression-related drivers inmyelodysplasticsyndromes. Feng Xu,et al. Nature communication. 2015, 26;6:8806.（IF= 11.47）（应用天昊创新技术：FastTarget）·       
        ?    Mutations in epigenetic regulators are involvedin acute lymphoblastic leukemia relapse following allogeneic hematopoietic celltransplantation. Xiao, H,et al.Oncotarget.2016,19;7(3):2696-708. （IF= 6.359）（应用天昊创新技术FastTarget）
 
 
天昊目的区域测序用于整篇文章的技术支撑案例：
       ?    Genomic variations of the mevalonate pathway inporokeratosis. Zhang Z,et al. Elife. 2015,23;4:e06322.（IF= 9.322）（应用天昊创新技EasyTarget®）
 
       不同于大量基因的目的区域测序，有一类文章只重点研究某一个基因的突变情况。发表的文章也是精彩纷呈，层次多样。小编今天为您准备了10篇不同档次的单个目的基因测序的文章，看看这些文章的研究思路是不是能给您带来新的灵感呢？  
      有灵感，天昊过硬的技术帮您实现灵感~
      没有灵感，天昊专业的团队也可以帮您寻找灵感~
 
 
参考文章：
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       2 Cuyvers E, De R A, Van d B T, et al. Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients: a targeted resequencing study[J]. Lancet Neurology, 2015, 14(8):814-822.
       3 Peykov S, Berkel S, Schoen M, et al. Identification and functional characterization of rareSHANK2variants in schizophrenia[J]. Molecular Psychiatry, 2015, 20(12):1489-1498.
       4 Davidson S I, Jiang L, Cortes A, et al. Brief Report: High-Throughput Sequencing of IL23R, Reveals a Low-Frequency, Nonsynonymous Single-Nucleotide Polymorphism That Is Associated With Ankylosing Spondylitis in a Han Chinese Population[J]. Arthritis & Rheumatism, 2013, 65(9):1747-52.
       5 Kimura H, Tsuboi D, Wang C, et al. Identification of Rare, Single-Nucleotide Mutations in NDE1 and Their Contributions to Schizophrenia Susceptibility[J]. Schizophrenia Bulletin, 2015, 41(3):744.
       6 Chien W H, Gau S S, Liao H M, et al. Deep exon resequencing of DLGAP2 as a candidate gene of autism spectrum disorders[J]. Molecular Autism, 2013, 4(1):26.
       7 Chen X, An Y, Gao Y, et al. Rare Deleterious PARD3 Variants in the aPKC-Binding Region are Implicated in the Pathogenesis of Human Cranial Neural Tube Defects via Disrupting Apical Tight Junction Formation[J]. Human Mutation, 2016. （客户文章）
       8 Yang X, Zhao Q, An R, et al. Mutational scanning of the CHCHD2 gene in Han Chinese patients with Parkinson's disease and meta-analysis of the literature[J]. Parkinsonism & Related Disorders, 2016, 29:42-46. （客户文章）
       9 Yang X, An R, Zhao Q, et al. Mutational analysis of CHCHD2 in Chinese patients with multiple system atrophy and amyotrophic lateral sclerosis[J]. Journal of the Neurological Sciences, 2016, 368:389-391. （客户文章）
      10 Yang X, An R, Xi J, et al. Sequence TMEM230 gene in patients with multiple system atrophy in a southwest Chinese population: A pilot study[J]. Journal of the Neurological Sciences, 2017, 375:264-265. （客户文章）